Nevertheless, there may be cases where both can be used together if it represents the best therapy
If you're taking a statin and are 65 or older, steering clear of the antibiotics Biaxin (clarithromycin) and erythromycin can help keep you safe from some uncommon — but potentially 1
inhibited, P-gp-mediated transport inhibited, hepatic transport inhibited) Erythromycin is an antibiotic that's used to treat a variety of infections caused by bacteria, including certain skin and respiratory infections
Telithromycin, clarithromycin, and erythromycin are the most "offending" macrolides, while azithromycin appears to be safe to use with Several reports and controlled studies have shown that erythromycin may interact with theophylline, carbamazepine, cyclosporin, tacrolimus, warfarin, digoxin, terfenadine, astemazole, cisapride, lovastatin, triazolam, and disopyramide
Based on mechanistic/clinical studies involving clarithromycin or the related macrolide erythromycin (both strong inhibitors of CYP3A4 and of hepatic statin uptake transporters OATP1B1 and OATP1B3), clarithromycin is expected to substantially increase systemic exposure to simvastatin and lovastatin (>5-fold increase in area under the plasma Moderate azithromycin lovastatin Applies to: azithromycin and lovastatin Using azithromycin together with lovastatin may increase your risk of a dangerous side effect on your muscles
There are 636 drugs known to interact with erythromycin, along with 5 disease interactions, and 2 alcohol/food interactions
Grapefruit and grapefruit juice can interact with many medications, including colchicine
In this study, gut microbiota-mediated DDI were investigated by studying the pharmacokinetics of lovastatin in antibiotic-treated rats
Arch Drug interactions can differ with various statins, including Crestor (rosuvastatin), Lescol (fluvastatin), Lipitor (atorvastatin), Mevacor (lovastatin), Pravachol (pravastatin), or Zocor (simvastatin)
Statins and CYP Interactions
Clinical Erythromycin is an antibiotic used for the treatment of a number of bacterial infections
involvement of the gut microbiota in lovastatin metabolism
In this study, gut microbiota-mediated DDI However, elderly patients are more likely to have erythromycin-induced hearing loss, heart rhythm problems, and bleeding problems
Long prescription periods and their pharmacokinetic characteristics increase the possibility of interactions, especially at the metabolism level
Phenytoin (mixed effects described) Ritonavir
The patient's medications should be analyzed closely for drug interactions with warfarin, especially when initiating or altering Based upon the in vitro data discussed above, clarithromycin's interaction potential with lovastatin, pitavastatin, rosuvastatin and fluvastatin may be inferred from PK studies involving erythromycin and the noted statins
As described above, this caution results from the ability of these two macrolide antibiotics to inhibit the CYP3A4 metabolism of lovastatin, simvastatin, and to a lesser extent The potential severity of these uncommon interactions warrants measures to avoid them
1 2 While the interactions between statins and other antibiotics are well documented, 3 the interaction between statins and ciprofloxacin is less so
Strong CYP3A4 inhibitors increase systemic statin exposure and risk of myopathy, including rhabdomyolysis trazodone increases levels of lovastatin by unspecified interaction Commonly used antimicrobials, such as macrolide antibiotics and azole antifungals, interact significantly with the CYP3A4 enzyme pathway similarly to lovastatin, simvastatin, and atorvastatin
A total of 104,041 statin users aged 66 or older from Ontario, Canada, were Learn about drug interactions between lovastatin oral and erythromycin stearate oral and use the RxList drug interaction checker to check drug combinations
Treatment generally lasts for at least 6 to 14 days, but in some Verapamil, cyclosporine, erythromycin, ketoconazole, and tamoxifen are examples of agents that have demonstrated either in vitro or in vivo inhibition of P-gp function
If there is concern about the co-administration of atorvastatin and grapefruit, a different statin can be used including Pravachol (pravastatin) , Lescol (fluvastatin) , Livalo Dosage for Erythromycin
Posaconazole
Combining these medications may significantly increase the blood levels of lovastatin
Rosuvastatin and fluvastatin are primarily metabolized by CYP2C9 43, 44
Lovastatin is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood
There is an interaction between Lipitor ( atorvastatin) and erythromycin
This activity will review the mechanism of action, adverse effects, and other key factors (e
"Co-prescription of either clarithromycin or erythromycin with atorvastatin, simvastatin, or lovastatin was associated with an increased risk of hospital admission
Simvastatin, lovastatin, and to lesser extent atorvastatin are the statins most affected by this interaction
Drug Interactions between atorvastatin and erythromycin This report displays the potential drug interactions for the following 2 drugs: atorvastatin erythromycin Edit list
Side effects Warnings Before taking Dosage Interactions FAQ What is lovastatin? Lovastatin is used together with diet to lower blood levels of "bad"
2008
Drug Interactions
Its structural formula is: Lovastatin is a white, nonhygroscopic crystalline powder that is insoluble in water and sparingly soluble in ethanol, methanol, and acetonitrile
Amiodarone: An interaction with this drug is more likely with simvastatin and lovastatin
Erythromycin comes in two forms that are From UKMi Medicines Q&A
The patient's medications should be analyzed closely for drug interactions with warfarin, especially when initiating or altering Based upon the in vitro data discussed above, clarithromycin's interaction potential with lovastatin, pitavastatin, rosuvastatin and fluvastatin may be inferred from PK studies involving erythromycin and the noted statins
These cases may require monitoring and dose adjustments or, in extreme cases, discontinuing LMA administration for the active treatment period with the antibiotic therapy
Accordingly, coadministration of drugs affecting the metabolic activities of gut microbes (e
Contraindicated
Ritonavir, a strong cytochrome P450 (CYP) 3A4 inhibitor and a P-glycoprotein (P-gp) inhibitor, is coadministered with nirmatrelvir to increase the blood concentration of nirmatrelvir, thereby making it effective against SARS-CoV-2